Acid-base balance in acute ethylene glycol poisoning in rats treated with fomepizole
نویسندگان
چکیده
منابع مشابه
Fomepizole for ethylene glycol and methanol poisoning.
n engl j med 360;21 nejm.org may 21, 2009 2216 This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are presented...
متن کاملEthylene glycol poisoning in a child treated with 4-methylpyrazole.
OBJECTIVE The alcohol dehydrogenase inhibitor 4-methylpyrazole (4-MP) is a new antidote of ethylene glycol (EG) intoxication. The purpose of the present case report was to demonstrate 4-MP efficiency in EG poisoning in a 4-year-old child. METHOD AND RESULTS 4-MP Treatment was performed 7 hours after EG ingestion. Plasma EG and 4-MP concentrations were measured 2 hours after each infusion of 4...
متن کاملTreatment of patients with ethylene glycol or methanol poisoning: focus on fomepizole
Ethylene glycol (EG) and methanol are responsible for life-threatening poisonings. Fomepizole, a potent alcohol dehydrogenase (ADH) inhibitor, is an efficient and safe antidote that prevents or reduces toxic EG and methanol metabolism. Although no study has compared its efficacy with ethanol, fomepizole is recommended as a first-line antidote. Treatment should be started as soon as possible, ba...
متن کاملAcute ethylene glycol poisoning after intentional ingestion
Background: We describe a case of acute ethylene glycol poisoning following ingestion of antifreeze agent in which serum ethylene glycol and anion gap were serially measured. Patients: A 66-year old man was hospitalized after intentional ingestion of automotive antifreeze. Upon admission, vital signs, mental status, and neurological functions were normal. Initial laboratory tests revealed no se...
متن کاملThe Role of Hemodialysis and Fomepizole in Ethylene Glycol Intoxication
Ethylene glycol is one of the most common toxic alcohol ingestions requiring hemodialysis for treatment. With the FDA approval in 1997 of fomepizole (4-methylpyrazole), the indications for hemodialysis in addition to fomepizole for ethylene glycol poisoning have been examined in recent articles and case reports. Fomepizole, a competitive inhibitor of alcohol dehydrogenase, binds to the same sit...
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ژورنال
عنوان ژورنال: Journal of Medical Science
سال: 2014
ISSN: 2353-9801,2353-9798
DOI: 10.20883/medical.e40